Bacterial degradation of microcystin toxins in drinking water eliminates their toxicity.

نویسندگان

  • Lionel Ho
  • Anne-Laure Gaudieux
  • Stella Fanok
  • Gayle Newcombe
  • Andrew R Humpage
چکیده

Microcystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal.

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عنوان ژورنال:
  • Toxicon : official journal of the International Society on Toxinology

دوره 50 3  شماره 

صفحات  -

تاریخ انتشار 2007